Seminar: Bacterial Pathogenesis: It’s all about secretion
Abstract: Citrobacter rodentium is a natural mouse pathogen that is used as a model to study pathogenic mechanisms of enteropathogenic and enterohemorrhagic E. coli. Using this natural infection model, we have been determining how this pathogen causes disease. The pathogen goes through a defined set of bottlenecks as it enters the host. Quorum sensing plays a role in establishing the infection. It uses a type III secretion system to deliver virulence factors to subvert host cells. However, it also uses a type II system as part of its pathogenesis, and has a type VI system that is used to counter the effects of resident microbes to successfully establish a niche. The various systems and components characterized will be discussed in the context of how this pathogen is able to subvert its host and microbiome to cause disease.
The Dmitry Apel Memorial Seminar (est. 2013) is an annual seminar that honours the memory of Dr. Dmitry Apel, a PhD student in Dr. Erin Gaynor’s lab who passed away in 2013. The seminar and its speakers are sponsored by Dmitry's family - specifically his sister and mother, Dr. Sabrina Apel and Dr. Maryana Apel. The goal of this seminar is to continue sharing Dmitry’s love of pure science and the search for scientific knowledge for its own sake.
If you are unable to make it in person, you can join us on Zoom:
Zoom: 92927 687268
ID: 687268
Seminar: Bacterial Pathogenesis: It’s all about secretion
Abstract: Citrobacter rodentium is a natural mouse pathogen that is used as a model to study pathogenic mechanisms of enteropathogenic and enterohemorrhagic E. coli. Using this natural infection model, we have been determining how this pathogen causes disease. The pathogen goes through a defined set of bottlenecks as it enters the host. Quorum sensing plays a role in establishing the infection. It uses a type III secretion system to deliver virulence factors to subvert host cells. However, it also uses a type II system as part of its pathogenesis, and has a type VI system that is used to counter the effects of resident microbes to successfully establish a niche. The various systems and components characterized will be discussed in the context of how this pathogen is able to subvert its host and microbiome to cause disease.
The Dmitry Apel Memorial Seminar (est. 2013) is an annual seminar that honours the memory of Dr. Dmitry Apel, a PhD student in Dr. Erin Gaynor’s lab who passed away in 2013. The seminar and its speakers are sponsored by Dmitry's family - specifically his sister and mother, Dr. Sabrina Apel and Dr. Maryana Apel. The goal of this seminar is to continue sharing Dmitry’s love of pure science and the search for scientific knowledge for its own sake.
If you are unable to make it in person, you can join us on Zoom:
Zoom: 92927 687268
ID: 687268