Horwitz Lab - Publications

  • Richer, M.J., Poffenberger, M. and Horwitz, M.S. Early Inflammatory responses direct chronic autoimmunity development in the heart following coxsackievirus infection. Future Virology, 2(3) 1-9, May, 2007.
  • Richer, M.J., Fang, D., Shanina, I. and Horwitz, M.S. Toll-like Receptor 4-induced cytokine production circumvents protection conferred by TGF-β in coxsackievirus mediated autoimmune myocarditis. Clinical Immunology, 121(3):339-49 in Press-online, September 11th, 2006.
  • Horwitz, M.S., Knudsen, M., Ilic, A., Fine, C., and Sarvetnick, N. TGF-β inhibits Coxsackievirus-mediated autoimmune myocarditis. Viral Immunology, 19(4):722-33 in Press, 2006. (cover photo)
  • Horwitz, M.S., Ilic, A., Fine, C., and Sarvetnick, N. Antigen specific peripheral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis. Journal of Autoimmunity, in Press-online July 11th, 2005.
  • Horwitz, M.S., Ilic, A., Fine, C., Balasa, B. and Sarvetnick, N. Coxsackievirus-mediated diabetes: Induction requires antigen presenting cells and is accompanied by phagocytosis of beta cells. Clinical Immunology, 110(2):134-44, 2004.
  • Robey, I.F., Peterson, M., Horwitz, M.S. , Kono, D.H., Stratmann, T. Theofilopoulos, A.N., Sarvetnick, N., Teyton, L. and Feeney, A.J. Terminal Deoxynucleotidyl Transferase Deficiency Decreases Autoimmune Disease in Diabetes-prone NOD Mice and Lupus-prone MRL-Faslpr Mice. Journal of Immunology, 172(7) 4624-29,2004.
  • Horwitz, M.S., Ilic, A., Fine, C., Rodriguez, E. and Sarvetnick, N. Coxsackievirus-mediated hyperglycemia is enhanced by re-infection and this occurs independent of T cells. Virology, 314: 510-520, 2003.
  • Horwitz, M.S., Ilic, A., Fine, C., Rodriguez, E. and Sarvetnick, N. Presented antigen from damaged pancreatic beta cells activates autoreactive T cells in virus-mediated autoimmune diabetes. Journal of Clinical Investigations, 109: 79-87, 2002.
  • Horwitz, M.S., Fine, C., Ilic, A. and Sarvetnick, N. Requirements for Viral-mediated Autoimmune Diabetes: beta cell damage and immune infiltration. Journal of Autoimmunity. 16(3): 211-218, 2001.
  • Flodstrom, M., Horwitz, M.S., Balakrishna, D., Maday, A., Rodriguez, E. and Sarvetnick, N. A critical role for inducible nitric oxide synthase in viral clearance and host survival following coxsackievirus B4 infection. Virology.281(2): 205-215, 2001.Horwitz, M.S., Ilic, A., Fine, C., and Sarvetnick, N. Antigen specific peripheral tolerance to cardiac myosin does not prevent CB3-mediated autoimmune myocarditis. Journal of Autoimmunity, in Press-online July 11th, 2005.
  • Horwitz, M.S., La Cava, A., Fine, C., Rodriguez, E., Ilic, A. and Sarvetnick, N. Pancreatic expression of interferon-gamma protects mice from lethal coxsackievirus B3 infection and subsequent myocarditis. Nature Medicine 6(6): 693-7, 2000. (Cover photo and News and Views, pp.631 )
  • Horwitz, M.S., Krahl, T., Lee, J., and Sarvetnick, N. Protection from lethal Coxsackie virus-induced pancreatitis by local expression of interferon-gamma. J. Virology 73(3): 1756-66, 1999.
  • Horwitz, M.S., Evans, C.F., Klier, F.G., and Oldstone, M.B.A. Detailed in vivo analysis of interferon-gamma induced MHC expression in the CNS: Astrocytes fail to express MHC class I and II molecules. Laboratory Investigations. 79(2): 235-242, 1999. (Cover photo and Inside L. I., pp.81)
  • Horwitz, M.S., Bradley, L.M., Harbertson, J., Krahl, T., Lee, J., and Sarvetnick, N. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry. Nature Medicine, 4(7): 781-785, 1998. (News & Views, pp. 770-1).
  • Horwitz, M.S., Evans, C.F., Rodriguez, M., and Oldstone, M.B.A. Primary Demyelination in Transgenic Mice Expressing Interferon-Gamma. Nature Medicine, 3(9):1037-1041, 1997.
  • Borrow, P., Lewicki, H., Wei, X., Horwitz, M.S. Peffer, N., Myers, H., Nelson, J., Gairin, J., Hahn, B., Oldstone, M.B.A., and Shaw, G. Antiviral pressure exerted by HIV-1-specific CTL during primary infection demonstrated by rapid selection of CTL escape virus. Nature Medicine, 3(2)205-211, 1997.
  • Horwitz, M.S., *Evans, C.F., Hobbs, M.V., and Oldstone., M.B.A. Viral infection of transgenic mice expressing a viral protein in Oligodendrocytes lends to chronic central nervous system autoimmune disease. J. Exp. Med., 184:2371-2384, 1996.
  • Horwitz, M.S., Yanagi, Y., and Oldstone, M.B.A. T cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine amino acid viral epitope show marked diversity. J. Virol. 68:352-357, 1994.
  • Horwitz, M.S., Boyce-Jacino, M.T., and Faras, A.J. Novel human endogenous sequences related to human immunodeficiency virus type I. J. Virol. 66:2170-2179, 1992.