Dr. Hirst lab played a key role in the NIH Epigenetic roadmap project, which resulted in 24 papers, Martin's lab was involved in four of these publications, 1 in Nature and 3 in Nature Communications.
The term “genome” refers to the entire DNA within our cells and the term “epigenome” refers to the chemical modifications of DNA and proteins that control the structure and activity of the genome. The genome remains mostly the same throughout an individual’s life, whereas epigenomes code for cellular properties that distinguish one cell type from another. Cells acquire epigenomes during development and under environmental influences, thus providing a key to understanding human health and the role of the environment in human diseases.
This collection of manuscripts generated by the NIH Roadmap Epigenomics Consortium describes the generation and analysis of reference epigenome maps from 111 distinct human cell and tissue types. Collectively this resource provides a 'vocabulary book' that helps scientists decipher the biochemical activities of each DNA segment in the context of 111 distinct cell and tissue types.