Gold Lab - Publications

Selected Research Articles

Bolger-Munro, M., Choi, K., Scurll, J., Abraham, L., Chappell, R., Sheen, D., Dang-Lawson, M., Wu, X., Priatel, J.J., Coombs, D., Hammer, J.A., Gold, M.R. (2019). Arp2/3 complex-driven spatial patterning of the B cell receptor (BCR) enhances immune synapse formation, BCR signaling, and cell activation. eLife.

Wang, J.C., Lee, J.Y.-J., Dang-Lawson, M., Pritchard, C., and Gold, M.R. (2018). The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center. Small GTPases 0, 1–11. .

Wang, J.C., Bolger-Munro, M., and Gold, M.R. (2018). Imaging the Interactions Between B Cells and Antigen-Presenting Cells. In: Methods in molecular biology (Clifton, N.J.), vol. 1707 Humana Press, New York, NY; 2018.p. 131–161., doi: 10.1007/978-1-4939-7474-0_10.

Wang, J.C., Bolger-Munro, M., and Gold, M.R. (2018). Visualizing the Actin and Microtubule Cytoskeletons at the B-cell Immune Synapse Using Stimulated Emission Depletion (STED) Microscopy. J. Vis. Exp. (134), e57028, doi:10.3791/57028.

Abraham, L., H.Y. Lu, R.C. Falcão, J. Scurll, T. Jou, B. Irwin, R. Tafteh, M.R. Gold, and D. Coombs (2017). Limitations of Qdot labelling compared to directly-conjugated probes for single particle tracking of B cell receptor mobility. Sci. Rep. 7, 11379. 

Wang, J.C., J.Y-J. Lee, S. Christian, M. Dang-Lawson, C. Pritchard, S.A. Freeman, and M.R. Gold (2017). The Rap1–cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse. J. Cell Sci. 130, 1094 LP-1109. 

Tafteh, R., L. Abraham, D. Seo, H.Y. Lu, M.R. Gold, and K.C. Chou (2016) Real-time 3D stabilization of a super-resolution microscope using an electrically tunable lens. Opt. Express 24, 22959-22970.

Klein T*, S-Y. Fung*, F. Renner*, M.A. Blank, A.Dufour, S. Kang, M. Bolger-Munro, J.M. Scurll, J.J. Priatel, P. Schweigler, S. Melkko,
M.R. Gold, R.I. Viner, C.H. Re ́gnier, S.E. Turvey, C.M. Overall (2015) The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling. Nat. Commun.

Freeman, S.A., V. Jaumouillé, K. Choi, B.E. Hsu, H.S. Wong, L. Abraham, M.L. Graves, D. Coombs, C.D. Roskelley, R. Das, S. Grinstein, M.R. Gold (2015) Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor. Nat. Commun.

Durand, C.A., M. Richer, K. Brenker, M. Graves, I. Shanina, K. Choi, M.S. Horwitz, K.D. Puri, and M.R. Gold (2013) Selective pharmacological inhibition of phosphoinositide 3-Kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice, Autoimmunity 46: 62-73.

Tse, K.W.K., K.B.L. Lin, M. Dang-Lawson, A. Guzman-Perez, G.E. Aspnes, L. Buckbinder, and M.R. Gold, Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells (2012) Cell. Immunol. 275: 47-54.

Freeman, S.A., V. Lei, M. Dang-Lawson, K. Mizuno, C.D. Roskelley, and M.R. Gold (2011) Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation, J. Immunol. 187: 5887-5900.  Reviewed in J. Immunol. “In this Issue” 187: 5471, 2011.

Freeman SA, McLeod SJ,  Dukowski J, Austin P, Lee CCY,  Miller-Martin B, Kubes P, McCafferty DM, Gold MR, Roskelley CD (2010) Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs. Cancer Research. 2010 Jun 1;70(11):4590-601.

Lin KB, Tan P, Freeman SA, Lam M, McNagny KM, Gold MR. (2010) The Rap GTPases regulate the migration, invasiveness and in vivo dissemination of B-cell lymphomas. Oncogene. 2010 Jan 28;29(4):608-15.

Durand CA, Hartvigsen K, Fogelstrand L, Kim S, Iritani S, Vanhaesebroeck B, Witztum JL, Puri KD, Gold MR. (2009) Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses. J Immunol. 2009 Nov 1;183(9):5673-84.

Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR.(2009) B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading. J Biol Chem. 2009 Aug 21;284(34):22865-77.

Lin, K.B.L., S.A. Freeman, S. Zabetian, H. Brugger, M. Weber, V. Lei, M. Dang-Lawson, K.W.K. Tse, R. Santamaria, F.D. Batista, and M.R. Gold (2008) The Rap GTPases regulate B cell morphology, immune synapse formation, and signaling by particulate B cell ligands, Immunity 28: 75-87.  Cover photo. Reviewed in Nature Rev. Immunol. 8: 168, 2008
Pub Med

Lee, R.L., J. Westendorf, and M.R. Gold (2007) Differential role of reactive oxygen species in the activation of mitogen-activated proteins kinases and Akt by CD40, the B cell antigen receptor, and CXCR4, J. Cell Commun. Signaling 1: 33-43.
Pub Med

Durand, C.A., J.Westendorf, K.W.K. Tse, and M.R. Gold (2006) The Rap GTPases mediate CXCL13- and sphingosine 1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B-lymphocytes, Eur. J. Immunol. 36:2235-2249. 
Pub Med

McLeod, S.J., A.J. Shum, R.L. Lee, F. Takei, and M.R. Gold (2004) The Rap GTPases regulate integrin-mediated adhesion, cell spreading, actin polymerization, and Pyk2 tyrosine phosphorylation in B lymphocytes, J. Biol. Chem. 279: 12009-12019.
Pub Med

Christian, S.L., R.L. Lee, S.J. McLeod, A.E. Burgess, A.H.Y. Li, M. Dang-Lawson, K.B.L. Lin, and M.R. Gold (2003) Activation of the Rap GTPases in B lymphocytes modulates B cell antigen receptor-induced activation of Akt but has no effect on MAP kinase activation, J. Biol. Chem. 278: 41756-41767.
Pub Med

 McLeod, S.J., A. H.Y. Li, R.L. Lee, A.E. Burgess, and M.R. Gold (2002) The Rap GTPases regulate B cell migration towards the chemokine SDF-1 (CXCL12). Potential role for Rap2 in promoting B cell migration, J. Immunol. 169: 1365-1371.
Pub Med

Christian, S.L, P.V. Sims, and M.R. Gold (2002) The B cell antigen receptor regulates the transcriptional activator b-catenin via protein kinase C-mediated inhibition of glycogen synthase-3, J. Immunol. 169: 758-769.
Pub Med

Ting, H.C., S.L. Christian, A.E. Burgess, and M.R. Gold (2002) Activation and phosphatidylinositol 3-kinase-dependent phosphorylation of protein kinase C-epsilon by the B cell antigen receptor, Immunology Lett. 82: 205-215. Pub Med

Zhu, N., L.M. Ramirez, R.L. Lee, N.S. Magnuson, G.A. Bishop, and M.R. Gold (2002) CD40 signaling in B cells regulates the expression of the Pim-1 kinase via the NF-B pathway, J. Immunol. 168: 744-754.
Pub Med


Review articles

Lin KB, Freeman SA, Gold MR. (2010) Rap GTPase-mediated adhesion and migration: A target for limiting the dissemination of B-cell lymphomas? Cell Adhesion and Migration 2010 Jul 4;4(3).

Gold, M.R. (2008) B cell development: Important work for ERK, Immunity 28: 488-490.
Pub Med

Gold, M.R. (2006) AKTion on mantle cell lymphoma, Blood 108: 1425-1426.  
Pub Med
Gold, M.R. (2003) Akt is TCL-ish: implications for B-cell lymphoma, Trends in Immunology 24: 104-108
Pub Med

Gold, M.R. (2002) To make antibodies or not: Signaling by the B cell antigen receptor, Trends in Pharmacological Sciences, 23: 316-324.
Pub Med