WILLIAM W. MOHN
Microbial Ecology, Diversity, and Geochemistry
The Mohn lab studies diverse topics in microbial catabolism and ecology, using classical, molecular, genomic and metagenomic approaches. We are investigating bacterial degradation of organic compounds, including steroids and lignocellulose, elucidating the catabolic pathways as well as the responsible organisms within the context of complex microbial communities. We are also investigating interactions between the early-life gut microbiome and developing immune system and determining how those interactions can lead to health or disease states, such as asthma. This research is relevant to the manufacture of bioproducts, environmental stewardship and human health.
Levy-Booth DJ, Hashimi A, Roccor R, Liu L, Renneckar S, Eltis LD, Mohn WW. 2020. Genomics and metatransciptomics of biogeochemical cycling and degradation of lignin-derived aromatic compounds in thermal swamp sediment. ISME J, doi.org/10.1038/s41396-020-00820-x
Cait A, Cardenas E, Dimitriu P, Amenyogbe N, Dai D, Cait J, Sbihi H, Stiemsma L, Subbarao P, Mandhane PJ, Becker AB, Moraes TJ, Sears MR, Lefebvre DL, Azad MB, Kollmann T, Turvey SE, Mohn WW. 2019. Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization. J Allergy Clin Immunol, 144:1638-1647
Holert J, Cardenas E, Bergstrand L, Zaikova E, Hahn A, Hallam SJ, Mohn WW. 2018. Metagenomes reveal global distribution of bacterial steroid catabolism in natural, engineered and host environments. mBio, 9:e02345-17